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take leave of sth. 有抛弃，告别，远离某物的意思，take leave of one's senses就是某人的理智和他告别了
to lose your good judgment
昏了头，失去理智
You can't take the children out sailing in this weather! Have you completely taken leave of your senses?
你不能在这样的天气里带孩子们出海!你疯了吗?