心脑血管福音：武汉大学发现新型降胆固醇化合物

Chinese researchers have discovered a new compound that can help lower cholesterol levels in the blood.

中国研究人员发现了一种新的化合物，可以帮助降低血液中的胆固醇水平。

Long-term high levels of cholesterol in the blood can cause atherosclerosis, which may lead to cardiovascular and cerebrovascular diseases.

血液中如果长期存在高水平的胆固醇，会导致动脉粥样硬化，进而引发心脑血管疾病。

Statins are the main clinical cholesterol-lowering drugs and are widely used in the prevention and treatment of cardiovascular diseases. However, statins increase side effects after treatment.

他汀类药物是目前临床上主要的降胆固醇药物，广泛应用于心脑血管疾病的防治。然而，采用他汀类药物治疗会产生副作用。

After a series of compound design and activity analysis, researchers from Wuhan University discovered a new compound that can lower cholesterol.

武汉大学的科研人员经过一系列化合物设计、优化和活性分析，发现了这种可以降低胆固醇的新化合物。

The compound Cmpd 81 reduced cholesterol levels as well as the formation of atherosclerotic plaques in mice with hypercholesterolemia and atherosclerosis. When this compound is combined with statins, it can further lower cholesterol levels.

这一化合物在高胆固醇血症和动脉粥样硬化小鼠模型中试验时，可降低胆固醇水平和减少动脉粥样硬化斑块的形成。这一化合物和他汀类药物联合应用时，可进一步降低胆固醇水平。

The research has broad application prospects in the treatment of cardiovascular diseases. The screening system in the research as well as the compound have been put in for patent applications.

这一研究成果在心脑血管疾病的治疗中具有广阔的应用前景。目前，此项研究相关的筛选系统和化合物均已申请专利。

The research was published in the journal Nature Communications.

这项最新研究成果发表在《自然通讯》期刊上。