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by any means 无论如何
by no means 绝不
By all means, I must visit my sick friend.
我一定要探望我生病的朋友。
You must get there by all means before dark.
你们一定在天黑之前到达那里。
A:Could I borrow your pen, please?
我可以借用你的钢笔吗?
B:By all means.
当然可以。